Clinical Significance of Serum Biomarkers in Pediatric Solid Mediastinal and Abdominal Tumors

نویسندگان

  • John A. Sandoval
  • Linda H. Malkas
  • Robert J. Hickey
چکیده

Childhood cancer is the leading cause of death by disease among U.S. children between infancy and age 15. Despite successes in treating solid tumors such as Wilms tumor, disappointments in the outcomes of high-risk solid tumors like neuroblastoma have precipitated efforts towards the early and accurate detection of these malignancies. This review summarizes available solid tumor serum biomarkers with a special focus on mediastinal and abdominal cancers in children.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

​Children\'s Abdominal Tumors: Symptomes -Diagnosis -Treatment

Malignancy is one of the most frequent cause of death in children -in U.S. it is the second common cause (second to Tranma). Between childhood malignancy leukemia is by far the mO'st frequent one and C.N.S. tumors take the second place -abdominal tumor re­main the third common cause of children's malignancy -Retroperitoneal space with organs like, kidney, adrenal gland, sympatheti nervous syste...

متن کامل

Biomarkers of Pediatric Brain Tumors

UNLABELLED Background and Need for Novel Biomarkers: Brain tumors are the leading cause of death by solid tumors in children. Although improvements have been made in their radiological detection and treatment, our capacity to promptly diagnose pediatric brain tumors in their early stages remains limited. This contrasts several other cancers where serum biomarkers such as cancer antigen (CA) 19-...

متن کامل

P154: Role of Exosomes as Novel Biomarkers in Diagnosis and Prognosis of Glioblastoma

Glioblastoma multiform(GBM) is the most prevalent primary brain tumor. Exosomes are extracellular vehicles for exchanging information between various cell types including cancer and normal cells. Exosomes are indicative of pathophysiological conditions of brain tumors that could be used in diagnosis and prognosis of GBM. In tumors, exosomes could carry various molecules like several miRNAs and ...

متن کامل

A review of 25 years experience in 461 cases of pediatric abdominal mass

Background: Regarding the significance of abdominal masses in children, we aimed to identify the pathology of masses according to the age and sex groups. Materials and Methods: We retrospectively reviewed pathological reports of 461 patients with abdominal mass that underwent resection or biopsy during the study period (25 years). Results: One hundred and eighty six cases (40%) were non-neo...

متن کامل

Solid tumors of childhood display specific serum microRNA profiles.

BACKGROUND Serum biomarkers for diagnosis and risk stratification of childhood solid tumors would improve the accuracy/timeliness of diagnosis and reduce the need for invasive biopsies. We hypothesized that differential expression and/or release of microRNAs (miRNAs) by such tumors may be detected as altered serum miRNA profiles. METHODS We undertook global quantitative reverse transcription ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 13  شماره 

صفحات  -

تاریخ انتشار 2012